2010

Johswich K, Martin M, Bleich A, Kracht M, Dittrich-Breiholz O, Gessner JE, Suerbaum S, Wende E, Rheinheimer C, Klos A.
Role of the C5a receptor (C5aR) in acute and chronic dextran sulfate-induced models of inflammatory bowel disease.
Inflamm Bowel Dis. 2009 Aug 27;15(12):1812-1823.
PubMed [PMID: 19714742]

Gaestel M, Kotlyarov A, Kracht M.
Targeting innate immunity protein kinase signalling in inflammation.
Nat Rev Drug Discov. 2009 Jun;8(6):480-99.

Lucchesi W, Brady G, Dittrich-Breiholz O, Kracht M, Russ R, Farrell PJ.
Differential gene regulation by Epstein-Barr virus type 1 and type 2 EBNA2.
J Virol. 2008 Aug;82(15):7456-66
PubMed

Wolter S, Doerrie A, Weber A, Schneider H, Hoffmann E, von der Ohe J, Bakiri L, Wagner EF, Resch K, Kracht M.
c-Jun controls histone modifications, NF-kappaB recruitment, and RNA polymerase II function to activate the ccl2 gene.
Mol Cell Biol. 2008 Jul;28(13):4407-23
PubMed

Hoffmann E, Ashouri J, Wolter S, Doerrie A, Dittrich-Breiholz O, Schneider H, Wagner EF, Troppmair J, Mackman N, Kracht M.
Transcriptional regulation of EGR-1 by the interleukin-1-JNK-MKK7-c-Jun pathway.
J Biol Chem. 2008 May 2;283(18):12120-8.
PubMed

Winzen R, Thakur BK, Dittrich-Breiholz O, Shah M, Redich N, Dhamija S, Kracht M, Holtmann H.
Functional analysis of KSRP interaction with the AU-rich element of interleukin-8 and identification of inflammatory mRNA targets.
Mol Cell Biol. 2007 Dec;27(23):8388-400. Epub 2007 Oct 1.
PubMed

Wang L, Brinkmann MM, Pietrek M, Ottinger M, Dittrich-Breiholz O, Kracht M, Schulz TF.
Functional characterization of the M-type K15-encoded membrane protein of Kaposi's sarcoma-associated herpesvirus.
J Gen Virol. 2007 Jun;88(Pt 6):1698-707.
PubMed

Brinkmann MM, Pietrek M, Dittrich-Breiholz O, Kracht M, Schulz TF.
Modulation of host gene expression by the K15 protein of Kaposi's sarcoma-associated herpesvirus.
J Virol. 2007 Jan;81(1):42-58. Epub 2006 Oct 18. PMID: 17050609 [PubMed - indexed for MEDLINE]
PubMed

Ronkina N, Kotlyarov A, Dittrich-Breiholz O, Kracht M, Hitti E, Milarski K, Askew R, Marusic S, Lin LL, Gaestel M, Telliez JB.
The mitogen-activated protein kinase (MAPK)-activated protein kinases MK2 and MK3 cooperate in stimulation of tumor necrosis factor biosynthesis and stabilization of p38 MAPK.
Mol Cell Biol. 2007 Jan;27(1):170-81
PubMed

Autenrieth SE, Soldanova I, Rösemann R, Gunst D, Zahir N, Kracht M, Ruckdeschel K, Wagner H, Borgmann S, Autenrieth IB.
Yersinia enterocolitica YopP inhibits MAP kinase-mediated antigen uptake in dendritic cells.
Cell Microbiol. 2007 Feb;9(2):425-37
PubMed

Kracht M..
Targeting Strategies to Modulate the NF-kappaB and JNK Signal Transduction Network . Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry 2007; 6: 71-84

Kracht, M., Holtmann, H. Cytokines. Invited contribution to „Encyclopedic references to molecular pharmacology“
Springer Verlag, (Update 2007)

Purwar R, Wittmann M, Zwirner J, Oppermann M, Kracht M, Dittrich-Breiholz O, Gutzmer R, Werfel T.
Induction of C3 and CCL2 by C3a in keratinocytes: a novel autocrine amplification loop of inflammatory skin reactions.
J Immunol. 2006 Oct 1;177(7):4444-50.
PubMed

Spender LC, Lucchesi W, Bodelon G, Bilancio A, Karstegl CE, Asano T, Dittrich-Breiholz O, Kracht M, Vanhaesebroeck B, Farrell PJ.
Cell target genes of Epstein-Barr virus transcription factor EBNA-2: induction of the p55alpha regulatory subunit of PI3-kinase and its role in survival of EREB2.5 cells.
J Gen Virol. 2006 Oct;87(Pt 10):2859-67.
PubMed

Ansari AW, Bhatnagar N, Dittrich-Breiholz O, Kracht M, Schmidt RE, Heiken H.
Host chemokine (C-C motif) ligand-2 (CCL2) is differentially regulated in HIV type 1 (HIV-1)-infected individuals.
Int Immunol. 2006 Oct;18(10):1443-51. Epub 2006 Aug 17.
PubMed

Thiefes A, Wolf A, Doerrie A, Grassl GA, Matsumoto K, Autenrieth I, Bohn E, Sakurai H, Niedenthal R, Resch K, Kracht M.
The Yersinia enterocolitica effector YopP inhibits host cell signalling by inactivating the protein kinase TAK1 in the IL-1 signalling pathway.
EMBO Rep. 2006 Aug;7(8):838-44. Epub 2006 Jul 14.
PubMed

Kettner-Buhrow D, Dittrich-Breiholz O, Schneider H, Wolter S, Resch K, Kracht M.
Small interfering RNAs generated by recombinant dicer induce inflammatory gene expression independent from the TAK1-NFkappaB-MAPK signaling pathways.
Biochem Biophys Res Commun. 2006 Sep 1;347(3):566-73. Epub 2006 Jun 30.
PubMed

Gowrishankar G, Winzen R, Dittrich-Breiholz O, Redich N, Kracht M, Holtmann H.
Inhibition of mRNA deadenylation and degradation by different types of cell stress.
Biol Chem. 2006 Mar;387(3):323-7.
PubMed

Schröder N, Sekhar A, Geffers I, Müller J, Dittrich-Breiholz O, Kracht M, Wedemeyer J, Gossler A.
Identification of mouse genes with highly specific expression patterns indifferentiated intestinal epithelium.
Gastroenterology. 2006 Mar;130(3):902-7.
PubMed

Mattioli I, Geng H, Sebald A, Hodel M, Bucher C, Kracht M, Schmitz ML.
Inducible phosphorylation of NF-kappa B p65 at serine 468 by T cell costimulation is mediated by IKK epsilon.
J Biol Chem. 2006 Mar 10;281(10):6175-83
PubMed

Gowrishankar G, Winzen R, Bollig F, Ghebremedhin B, Redich N, Ritter B, Resch K, Kracht M, Holtmann H.
Inhibition of mRNA deadenylation and degradation by ultraviolet light.
Biol Chem. 2005 Dec;386(12):1287-93.
PubMed

Breuer K, Wittmann M, Kempe K, Kapp A, Mai U, Dittrich-Breiholz O, Kracht M, Mrabet-Dahbi S, Werfel T.
Alpha-toxin is produced by skin colonizing Staphylococcus aureus and induces a T helper type 1 response in atopic dermatitis.
Clin Exp Allergy. 2005 Aug;35(8):1088-95.
PubMed

Schmeck B, Beermann W, van Laak V, Zahlten J, Opitz B, Witzenrath M, Hocke AC, Chakraborty T, Kracht M, Rosseau S, Suttorp N, Hippenstiel S.
Intracellular bacteria differentially regulated endothelial cytokine release by MAPK-dependent histone modification.
J Immunol. 2005 Sep 1;175(5):2843-50.
PubMed

Siegmund D, Wicovsky A, Schmitz I, Schulze-Osthoff K, Kreuz S, Leverkus M, Dittrich-Breiholz O, Kracht M, Wajant H.
Death receptor-induced signaling pathways are differentially regulated by gamma interferon upstream of caspase 8 processing.
Mol Cell Biol. 2005 Aug;25(15):6363-79.
PubMed

Peters J, Hess S, Endlich K, Thalmann J, Holzberg D, Kracht M, Schaefer M, Bartling G, Klos A.
Silencing or permanent activation: host-cell responses in models of persistent Chlamydia pneumoniae infection.
Cell Microbiol. 2005 Aug;7(8):1099-108.
PuMed

Thiefes A, Wolter S, Mushinski JF, Hoffmann E, Dittrich-Breiholz O, Graue N, Dörrie A, Schneider H, Wirth D, Luckow B, Resch K, Kracht M.
Simultaneous blockade of NFkappaB, JNK, and p38 MAPK by a kinase-inactive mutant of the protein kinase TAK1 sensitizes cells to apoptosis and affects a distinct spectrum of tumor necrosis factor [corrected] target genes.
J Biol Chem. 2005 Jul 29;280(30):27728-41. Epub 2005 Apr 18. Erratum in: J Biol Chem. 2005 Sep 16;280(37):32564.
PubMed

Hoffmann E, Thiefes A, Buhrow D, Dittrich-Breiholz O, Schneider H, Resch K, Kracht M.
MEK1-dependent delayed expression of Fos-related antigen-1 counteracts c-Fos and p65 NF-kappaB-mediated interleukin-8 transcription in response to cytokines or growth factors.
J Biol Chem. 2005 Mar 11;280(10):9706-18
PubMed

Buss H, Dörrie A, Schmitz ML, Hoffmann E, Resch K, Kracht M.
Constitutive and interleukin-1-inducible phosphorylation of p65 NF-{kappa}B at serine 536 is mediated by multiple protein kinases including I{kappa}B kinase (IKK)-{alpha}, IKK{beta}, IKK{epsilon}, TRAF family member-associated (TANK)-binding kinase 1 (TBK1), and an unknown kinase and couples p65 to TATA-binding protein-associated factor II31-mediated interleukin-8 transcription.
J Biol Chem. 2004 Dec 31;279(53):55633-43. Epub 2004 Oct 15.
PubMed

Schmeck B, Zahlten J, Moog K, van Laak V, Huber S, Hocke AC, Opitz B, Hoffmann E, Kracht M, Zerrahn J, Hammerschmidt S, Rosseau S, Suttorp N, Hippenstiel S.
Streptococcus pneumoniae-induced p38 MAPK-dependent phosphorylation of RelA at the interleukin-8 promotor.
J Biol Chem. 2004 Dec 17;279(51):53241-7. Epub 2004 Oct 13.
PubMed

Buss H, Dörrie A, Schmitz ML, Frank R, Livingstone M, Resch K, Kracht M.
Phosphorylation of serine 468 by GSK-3beta negatively regulates basal p65 NF-kappaB activity.
J Biol Chem. 2004 Nov 26;279(48):49571-4. Epub 2004 Oct 1.
PubMed

Kreuz S, Siegmund D, Rumpf JJ, Samel D, Leverkus M, Janssen O, Häcker G, Dittrich-Breiholz O, Kracht M, Scheurich P, Wajant H.
NFkappaB activation by Fas is mediated through FADD, caspase-8, and RIP and is inhibited by FLIP.
J Cell Biol. 2004 Aug 2;166(3):369-80.
PubMed

Mattioli I, Dittrich-Breiholz O, Livingstone M, Kracht M, Schmitz ML.
Comparative analysis of T-cell costimulation and CD43 activation reveals novel signaling pathways and target genes.
Blood. 2004 Nov 15;104(10):3302-4. Epub 2004 Jul 27.
PubMed

Mattioli I, Sebald A, Bucher C, Charles RP, Nakano H, Doi T, Kracht M, Schmitz ML.
Transient and selective NF-kappa B p65 serine 536 phosphorylation induced by T cell costimulation is mediated by I kappa B kinase beta and controls the kinetics of p65 nuclear import.
J Immunol. 2004 May 15;172(10):6336-44.
PubMed

Reviews

Kracht, M., Holtmann, H. Cytokines. Invited contribution to „Encyclopedic reference of Genomics and Proteomics in Molecular Medicine“,
Springer Verlag, in press, (2004)

Grassl GA, Kracht M, Wiedemann A, Hoffmann E, Aepfelbacher M, von Eichel-Streiber C, Bohn E, Autenrieth IB.
Activation of NF-kappaB and IL-8 by Yersinia enterocolitica invasin protein is conferred by engagement of Rac1 and MAP kinase cascades.
Cell Microbiol. 2003 Dec;5(12):957-71.
PubMed

Bömmel H, Haake M, Luft P, Horejs-Hoeck J, Hein H, Bartels J, Schauer C, Pöschl U, Kracht M, Duschl A.
The diesel exhaust component pyrene induces expression of IL-8 but not of eotaxin.
Int Immunopharmacol. 2003 Oct;3(10-11):1371-9.
PubMed

Holzberg D, Knight CG, Dittrich-Breiholz O, Schneider H, Dörrie A, Hoffmann E, Resch K, Kracht M.
Disruption of the c-JUN-JNK complex by a cell-permeable peptide containing the c-JUN delta domain induces apoptosis and affects a distinct set of interleukin-1-induced inflammatory genes.
J Biol Chem. 2003 Oct 10;278(41):40213-23. Epub 2003 Jun 27.
PubMed

Sarker KP, Biswas KK, Yamakuchi M, Lee KY, Hahiguchi T, Kracht M, Kitajima I, Maruyama I.
ASK1-p38 MAPK/JNK signaling cascade mediates anandamide-induced PC12 cell death.
J Neurochem. 2003 Apr;85(1):50-61.
PubMed

Dittrich-Breiholz, O., Schneider, H., Wehmeier, L., Resch, K., Kracht, M.
Entwicklung und Evaluierung eines DNA Mikro Arrays für entzündungsrelevante
Gene. Biospektrum 1/03, 88-92 (2003)

Wehmeier, L., Dittrich-Breiholz, O., Kracht, M.
Biochips in klinischen Applikationen: Ermittlung von Genexpressionsprofilen im Entzündungsprozess.
Managment und Krankenhaus, (2003)

Bollig F, Winzen R, Kracht M, Ghebremedhin B, Ritter B, Wilhelm A, Resch K, Holtmann H.
Evidence for general stabilization of mRNAs in response to UV light.
Eur J Biochem. 2002 Dec;269(23):5830-9.
PubMed

Hipp MS, Urbich C, Mayer P, Wischhusen J, Weller M, Kracht M, Spyridopoulos I.
Proteasome inhibition leads to NF-kappaB-independent IL-8 transactivation in human endothelial cells through induction of AP-1.
Eur J Immunol. 2002 Aug;32(8):2208-17.
PubMed

Wolter S, Mushinski JF, Saboori AM, Resch K, Kracht M.
Inducible expression of a constitutively active mutant of mitogen-activated protein kinase kinase 7 specifically activates c-JUN NH2-terminal protein kinase, alters expression of at least nine genes, and inhibits cell proliferation.
J Biol Chem. 2002 Feb 1;277(5):3576-84. Epub 2001 Nov 19.
PubMed

Hoffmann E, Dittrich-Breiholz O, Holtmann H, Kracht M.
Multiple control of interleukin-8 gene expression.
J Leukoc Biol. 2002 Nov;72(5):847-55. Review.
PubMed

Kracht M..
Signal-dependent regulation of interleukin-8 gene expression. In: Recent Research Developments in Molecular and Cellular Biology, Research Signpost, Trivandrum, India, (2001), Recent Res.Devel.Mol.Cell.Biol., 3:329-342, (2002) (Review)

Kracht, M., Holtmann, H. Cytokines. Invited contribution to „Encyclopedic references to molecular pharmacology“
Springer Verlag, (2002)

Ludwig S, Ehrhardt C, Neumeier ER, Kracht M, Rapp UR, Pleschka S.
Influenza virus-induced AP-1-dependent gene expression requires activation of the JNK signaling pathway.
J Biol Chem. 2001 Apr 6;276(14):10990-8. Epub 2001 Jan 9. Corrected and republished in: J Biol Chem. 2001 Jun 15;276(24):10990-8.
PubMed

Nourbakhsh M, Kalble S, Dorrie A, Hauser H, Resch K, Kracht M.
The NF-kappa b repressing factor is involved in basal repression and interleukin (IL)-1-induced activation of IL-8 transcription by binding to a conserved NF-kappa b-flanking sequence element.
J Biol Chem. 2001 Feb 9;276(6):4501-8.
PubMed

Holtmann H, Enninga J, Kalble S, Thiefes A, Dorrie A, Broemer M, Winzen R, Wilhelm A, Ninomiya-Tsuji J, Matsumoto K, Resch K,
Kracht M.
The MAPK kinase kinase TAK1 plays a central role in coupling the interleukin-1 receptor to both transcriptional and RNA-targeted mechanisms of gene regulation.
J Biol Chem. 2001 Feb 2;276(5):3508-16.
PubMed

Kracht M.
Regulation of cytokine transcription by common stress kinase cascades.
Eur Cytokine Netw. 2000 Sep;11(3):497-9
PubMed

Varga G, Dreikhausen U, Kracht M, Appel A, Resch K, Szamel M.
Molecular mechanisms of T lymphocyte activation: convergence of T cell antigen receptor and IL-1 receptor-induced signaling at the level of IL-2 gene transcription.
Int Immunol. 1999 Nov;11(11):1851-62.
PubMed

Holtmann H, Winzen R, Holland P, Eickemeier S, Hoffmann E, Wallach D, Malinin NL, Cooper JA, Resch K, Kracht M. Induction of interleukin-8 synthesis integrates effects on transcription and mRNA degradation from at least three different cytokine- or stress-activated signal transduction pathways.
Mol Cell Biol. 1999 Oct;19(10):6742-53.
PubMed

Winzen R, Kracht M, Ritter B, Wilhelm A, Chen CY, Shyu AB, Müller M, Gaestel M, Resch K, Holtmann H.
The p38 MAP kinase pathway signals for cytokine-induced mRNA stabilization via MAP kinase-activated protein kinase 2 and an AU-rich region-targeted mechanism.
EMBO J. 1999 Sep 15;18(18):4969-80.
PubMed

Krause A, Holtmann H, Eickemeier S, Winzen R, Szamel M, Resch K, Saklatvala J, Kracht M.
Stress-activated protein kinase/Jun N-terminal kinase is required for interleukin (IL)-1-induced IL-6 and IL-8 gene expression in the human epidermal carcinoma cell line KB.
J Biol Chem. 1998 Sep 11;273(37):23681-9.
PubMed

1997

Finch A, Holland P, Cooper J, Saklatvala J, Kracht M.
Selective activation of JNK/SAPK by interleukin-1 in rabbit liver is mediated by MKK7.
FEBS Lett. 1997 Nov 24;418(1-2):144-8.
PubMed

Wesche H, Korherr C, Kracht M, Falk W, Resch K, Martin MU.
The interleukin-1 receptor accessory protein (IL-1RAcP) is essential for IL-1-induced activation of interleukin-1 receptor-associated kinase (IRAK) and stress-activated protein kinases (SAP kinases).
J Biol Chem. 1997 Mar 21;272(12):7727-31.
PubMed

Appel A, Kracht M, Petersen K, Resch K, Szamel M.
Interleukin-1 induced signalling: biphasic activation of mitogen-activated protein kinase kinase and mitogen-activated protein kinases in HeLa cells. Involvement of phosphoprotein phosphatases.
Eur Cytokine Netw. 1996 Dec;7(4):775-84.
PubMed

Uciechowski P, Saklatvala J, von der Ohe J, Resch K, Szamel M, Kracht M.
Interleukin 1 activates jun N-terminal kinases JNK1 and JNK2 but not extracellular regulated MAP kinase (ERK) in human glomerular mesangial cells. FEBS Lett. 1996 Oct 7;394(3):273-8.
PubMed

Zinck R, Cahill MA, Kracht M, Sachsenmaier C, Hipskind RA, Nordheim A.
Protein synthesis inhibitors reveal differential regulation of mitogen-activated protein kinase and stress-activated protein kinase pathways that converge on Elk-1.
Mol Cell Biol. 1995 Sep;15(9):4930-8.
PubMed

Kracht M, Truong O, Totty NF, Shiroo M, Saklatvala J.
Interleukin 1 alpha activates two forms of p54 alpha mitogen-activated protein kinase in rabbit liver.
J Exp Med. 1994 Dec 1;180(6):2017-25.
PubMed

Kracht M, Shiroo M, Marshall CJ, Hsuan JJ, Saklatvala J.
Interleukin-1 activates a novel protein kinase that phosphorylates the epidermal-growth-factor receptor peptide T669.
Biochem J. 1994 Sep 15;302 ( Pt 3):897-905.
PubMed

Saklatvala J, Rawlinson LM, Marshall CJ, Kracht M.
Interleukin 1 and tumour necrosis factor activate the mitogen-activated protein (MAP) kinase kinase in cultured cells.
FEBS Lett. 1993 Nov 15;334(2):189-92.
PubMed

Kracht M, Heiner A, Resch K, Szamel M.
Interleukin-1-induced signaling in T-cells. Evidence for the involvement of phosphatases PP1 and PP2A in regulating protein kinase C-mediated protein phosphorylation and interleukin-2 synthesis.
J Biol Chem. 1993 Oct 5;268(28):21066-72.
PubMed

1990

Szamel M, Kracht M, Krebs B, Hübner U, Resch K.
Activation signals in human lymphocytes: interleukin 2 synthesis and expression of high affinity interleukin 2 receptors require differential signalling for the activation of protein kinase C.
Cell Immunol. 1990 Mar;126(1):117-28.
PubMed